NFL Predictions Against The Spreadīy some margin, the most popular wager amongst NFL bettors, and is unique in that it is widely discussed amongst sportscasters and the media leading up to the matches each week in the NFL. Aside from the NFL Against the Spread markets, other popular markets include over/under, parlays, prop bets, daily fantasy sports, or even scoreboard squares, there is a wager type for every kind of football fan. There is almost an infinite amount of ways to wager on a game, but the most popular wager amongst NFL bettors is Against the Spread betting, where you’re taking a team to win by more or lose by less than the spread set by the oddsmakers. There are up to 16 games each week and in a relatively short season, it heightens the importance of each game, increasing the interest and making NFL betting by far the most popular sport to wager on in the US. The NFL season is a short one, compared to the majority of major sports, at just 18 weeks long the NFL regular season feels as though it’s over in a flash.